Document Type : Scientific-Extensional Article
Author
Plant protection University of Tehran
Abstract
Quorum Sensing (QS) systems are among the most important regulatory mechanisms in Gram-negative bacteria, enabling intra-population chemical communication and the coordinated control of cell density–dependent behaviors. Among these bacteria, Pectobacterium carotovorum subsp. carotovorum (Pcc) is recognized as one of the principal causal agents of soft rot disease in cultivated crops. The QS network in this bacterium operates based on N-acyl homoserine lactone (AHL) signal molecules and is regulated through the ExpI/ExpR pathway. This system plays a key role in disease development by controlling the expression of a set of virulence genes, including plant cell wall–degrading enzymes (PCWDEs), bacterial motility, and the secretion of pathogenicity factors. In recent years, Quorum Quenching (QQ) strategies have been developed to inhibit QS activity through AHL-degrading enzymes or LuxR receptor inhibitors, which can reduce pathogenicity without imposing the selective pressure associated with antibiotics. This article provides a comprehensive review of the molecular, genetic, and biochemical findings of the past two decades, examining the structure and function of QS and QQ networks in Pcc, and analyzing the relationship between these two pathways while discussing the challenges and practical prospects of biological control based on the disruption of bacterial communication.
Highlights
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